Global Health
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Rapid, antibiotic incubation-free determination of tuberculosis drug resistance using machine learning and Raman spectroscopy
Tuberculosis (TB) is the world’s deadliest infectious disease, with over 1.5 million deathsand 10 million new cases reported anually. The causative organism Mycobacterium tuber-culosis (Mtb) can take nearly 40 d to culture, a required step to determine the pathogen’santibiotic susceptibility. Both rapid identification and rapid antibiotic susceptibility testingof Mtb are essential for effective patient treatment…
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Sharpness-Aware Minimization (SAM) Improves Classification Accuracy of Bacterial Raman Spectral Data Enabling Portable Diagnostics
Antimicrobial resistance is expected to claim 10 million lives per year by 2050, and resource-limited regions are most affected. Raman spectroscopy is a novel pathogen diagnostic approach promising rapid and portable antibiotic resistance testing within a few hours, compared to days when using gold standard methods. However, current algorithms for Raman spectra analysis 1) are…