Our Publications

More than magnetic isolation: Dynabeads as strong Raman reporters toward simultaneous capture and identification of targets

Dynabeads are superparamagnetic particles used for immunomagnetic purification of cells and biomolecules. Post-capture, however, target identification relies on tedious culturing, fluorescence staining and/or target amplification. Raman spectroscopy presents a rapid detection alternative, but current implementations target cells themselves with weak Raman signals. We present antibody-coated Dynabeads as strong Raman reporter labels…

Combining acoustic bio printing with AI-assisted Raman spectroscopy for high-throughput identification of bacteria in blood

Identifying pathogens in complex samples such as blood, urine, and wastewater is critical to detect infection and inform optimal treatment. Surface-enhanced Raman spectroscopy (SERS) and machine learning (ML) can distinguish among multiple pathogen species, but processing complex fluid samples to sensitively and specifically detect pathogens emails an outstanding challenge. Here, we develop an acoustic bio printer to digitize samples into millions of droplets….

Toward rapid infectious disease diagnosis with advances in surface-enhanced Raman spectroscopy

In a pandemic era, rapid infectious disease diagnosis is essential. Surface-enhanced Raman spectroscopy (SERS) promises sensitive and specific diagnosis including rapid point-of-care detection and drug susceptibility testing. SERS utilizes inelastic light….

Plasmonic and Electrostatic Interactions Enable Uniformly Enhanced Liquid Bacterial Surface-Enhanced Raman Scattering (SERS)

Surface-enhanced Raman spectroscopy (SERS) is a promising cellular identification and drug susceptibility testing platform, provided it can be performed in a controlled liquid environment that maintains cell viability. We investigate bacterial…..

Nanophotonic Platforms for Chiral Sensing and Separation

Chirality in Nature can be found across all length scales, from the subatomic to the galactic. At the molecular scale, the spatial dissymmetry in the atomic arrangements of pairs of mirror-image molecules, known as enantiomers, gives rise to fascinating and often critical differences in chemical and physical properties. With increasing….

Effect of Transition Metal Oxide Cathodes on the Oxygen Evolution Reaction in Li–O2 Batteries

Li–oxygen batteries could provide energy density that is up to five times greater than that of state-of-the-art Li-ion batteries. However, Li–oxygen cell rechargeability is limited by cathode passivation due to nonconductive discharge products. Despite efforts to efficiently oxidize these products, oxygen recovery remains poor at potentials where cell constituents are stable. Transition metal oxide (TMO) cathodes have shown low charging potentials, but…..

Cooperative enhancement of the nonlinear optical response in conjugated energetic materials: A TD-DFT study

Conjugated energetic molecules (CEMs) are a class of explosives with high nitrogen content that posses both enhanced safety and energetic performance properties and are ideal for direct optical initiation. As isolated molecules, they absorb within the range of conventional lasers. Crystalline CEMs are used….

Biotemplating pores with size and shape diversity for Li-oxygen Battery Cathodes

Synthetic porogens provide an easy way to create porous structures, but their usage is limited due to synthetic difficulties, process complexities and prohibitive costs. Here we investigate the use of bacteria, sustainable and naturally abundant materials, as a pore template. The bacteria….

Our Patents

Polymer-coated beads serving as Raman reporter for simultaneous target binding and identification

Filed, Appl. No. : 63/501,380

Label-free, real-time, whole-cell response monitoring with liquid Raman spectroscopy.

Filed, Appl. No.: PCT/US2021/048668.2021

Biotemplating pores with size and shape diversity for Li-oxygen Battery Cathodes.

Porous sheets US20180050913A1, 2018