Our Publications
More than magnetic isolation: Dynabeads as strong Raman reporters toward simultaneous capture and identification of targets
Dynabeads are superparamagnetic particles used for immunomagnetic purification of cells and biomolecules. Post-capture, however, target identification relies on tedious culturing, fluorescence staining and/or target amplification. Raman spectroscopy presents a rapid detection alternative, but current implementations target cells themselves with weak Raman signals. We present antibody-coated Dynabeads as strong Raman reporter labels…
Combining acoustic bio printing with AI-assisted Raman spectroscopy for high-throughput identification of bacteria in blood
Identifying pathogens in complex samples such as blood, urine, and wastewater is critical to detect infection and inform optimal treatment. Surface-enhanced Raman spectroscopy (SERS) and machine learning (ML) can distinguish among multiple pathogen species, but processing complex fluid samples to sensitively and specifically detect pathogens emails an outstanding challenge. Here, we develop an acoustic bio printer to digitize samples into millions of droplets….
Toward rapid infectious disease diagnosis with advances in surface-enhanced Raman spectroscopy
Plasmonic and Electrostatic Interactions Enable Uniformly Enhanced Liquid Bacterial Surface-Enhanced Raman Scattering (SERS)
Nanophotonic Platforms for Chiral Sensing and Separation
Chirality in Nature can be found across all length scales, from the subatomic to the galactic. At the molecular scale, the spatial dissymmetry in the atomic arrangements of pairs of mirror-image molecules, known as enantiomers, gives rise to fascinating and often critical differences in chemical and physical properties. With increasing….